Seroquel Safety Studies: More Information Uncovered
Bloomberg reports that AstraZeneca “buried” unfavorable studies on its antipsychotic drug Seroquel, according to an internal e-mail unsealed as part of litigation over the medicine.
Specifically, Seroquel’s manufacturer is accused of doing what has been alleged of drug companies thousands of times over the course of human history: failing to publicize results of at least three Seroquel clinical trials and cherry picking the data that it did publish about the risks associated with Seroquel.
Apparently, Seroquel’s manufacturer saw the whole thing coming: John Tumas, an AstraZeneca publications manager, wrote in an email that AstraZeneca had “buried trials 15, 31, 56.” Tumas showed in the email that he realized burying Seroquel data was not without risk:
The larger issue is how we face the outside world when they begin to criticize us for suppressing data.
Of course, this was hardly a one man conspiracy. Seroquel had engaged in a “great smoke-and-mirrors job” in dealing with U.S. and Canadian investigators on the trial’s results, according to an email from Richard Lawrence, an AstraZeneca official, in February 1997:
Adopting the approach Don has outlined should minimize (and dare I venture to suggest) could put a positive spin (in terms of safety) on this cursed study.
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